I am on entirely too many email lists for genealogy. Finally at long last I sat down in my gmail (which I use for my genealogy email) and made a separate filter for each one. Messages to these mailing lists then never go to my main inbox and I don't see them unless I visit the folder individually.
Now my inbox is not overflowing with these messages and I my inbox can stay clear for the "important" ones. This is particularly helpful as I get my genealogy email on my blackberry and before the filter I was ALWAYS getting email on my phone. A little annoying.
Email lists are great for genealogy, but now I can read them when I want--not have them flying at me 24/7.